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Your Position: Home > IL-2 R beta

IL-2 R beta

Brief Information

Name:Interleukin-2 receptor beta chain
Target Synonym:IL2RB,IMD63,IL-2RB,p75,CD122,Interleukin 2 Receptor Subunit Beta,Interleukin-15 Receptor Subunit Beta,Interleukin 15 Receptor, Beta,Interleukin 2 Receptor, Beta,IL-2R Subunit Beta,CD122 Antigen,P70-75,IL15RB,High Affinity IL-2 Receptor Beta Subunit,Interleukin-2 Receptor beta Subunit,Interleukin-2 receptor subunit beta,IL-2 receptor subunit beta,High affinity IL-2 receptor subunit beta
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:14
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
ILB-C52H9 Cynomolgus Cynomolgus IL-2 R beta / CD122 Protein, His Tag (MALS verified)
ILB-C52H9-structure
ILB-C52H9-sds
ILB-M5253 Mouse Mouse IL-2 R beta / CD122 Protein, Fc Tag
ILB-M5253-structure
ILB-M5253-sds
ILA-C52H5 Canine Canine IL-2 R beta Protein, His Tag
ILA-C52H5-structure
ILA-C52H5-sds
ILA-M52H5 Mouse Mouse IL-2 R beta Protein, His Tag
ILA-M52H5-structure
ILA-M52H5-sds
ILB-H82E3 Human Biotinylated Human IL-2 R beta / CD122 Protein, His,Avitag™
ILB-H82E3-structure
ILB-H82E3-sds
ILB-H5253 Human Human IL-2 R beta / CD122 Protein, Fc Tag (MALS & SPR verified)
ILB-H5253-structure
ILB-H5253-sds
CD2-H5221 Human Human IL-2 R beta / CD122 Protein, His Tag (SPR verified)
CD2-H5221-structure
CD2-H5221-sds
ACRO Quality

Part of Bioactivity data

CD2-H5221-Cell-based assay
IL-2 R beta CELL

Human IL-2 R beta Protein, His Tag (Cat. No. CD2-H5221) inhibits the IL-15-dependent proliferation of Mo7e cells. The EC50 for this effect is 0.38-0.45 µg/mL (Routinely tested).

Protocol
ILB-C52H9-SPR
IL-2 R beta SPR

Cynomolgus IL-2 R beta, His Tag (Cat. No. ILB-C52H9) immobilized on CM5 Chip can bind Cynomolgus IL-2, His Tag (Cat. No. IL2-C5249) with an affinity constant of 377 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
ILB-M5253-SPR
IL-2 R beta SPR

Mouse IL-2, His Tag (Cat. No. IL2-M52H3) immobilized on CM5 Chip can bind Mouse IL-2 R beta, Fc Tag (Cat. No. ILB-M5253) with an affinity constant of 36.2 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

IL2RB,RP5-1170K4.6,CD122,P70-75

Background

Interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2. The IL-2R is made up of 3 subunits - α (CD25), β (CD122) and γ (CD132) - non-covalently associating. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit. CD122 is also known as IL2R beta, is a member of the type I cytokine receptor family. CD122 is the receptor for interleukin-2 and is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

Clinical and Translational Updates

Related Molecule

IL-2 IL-15

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